Microbion is a clinical-stage pharmaceutical company developing a novel class of compounds for the treatment of difficult-to-treat infections, including chronic infections and antibiotic-resistant infections.
Microbion is dedicated to developing best-in-class, novel medicines that uniquely address key unmet medical needs and thereby provide physicians with durable, breakthrough options to improve and extend the lives of patients.
Pravibismane, our lead therapeutic candidate, is the first in a new class of anti-infective drugs with broad-spectrum activity and a novel mechanism of action that halts microbial cellular metabolism. Pravibismane has an unprecedented ability to prevent and eradicate biofilms that contribute to chronic infection and facilitate antibiotic-resistance. Microbion's has two Phase 2 clinical stage programs for topical/local treatment of diabetic foot ulcer infection and orthopedic device related infection, and one pre-clinical program for the inhalation treatment of chronic lung infection.
Microbion’s site specific delivery approach avoids systemic administration of our compounds that potentially: enables higher therapeutic concentration of drug at site of infection resulting in greater efficacy; reduces off-target effects and toxicity resulting in an improved safety profile; and lowers risk of developing antibiotic resistance that is associated with systemic antibiotic administration. The combination of these advantageous characteristics creates a favorable commercial opportunity.
Microbial biofilms are structured communities of bacterial cells enclosed in a self-produced matrix that provides a protective shield for bacteria to thrive and resist damage from many extreme environmental conditions. Pravibismane uniquely and potently eradicates bacteria and the biofilms they form.
Microbion has two Phase 2 clinical programs in diabetic foot ulcer infection and orthopedic implant infection. In addition, preclinical programs are under development for multiple therapeutic indications, including the treatment of serious respiratory infections.